Multimodal Non-Invasive Skin Imaging in Dermatology: Current Modalities, Clinical Applications, and Future Integration.

Multimodal non-invasive skin imaging combines complementary technologies, including dermoscopy, reflectance confocal microscopy (RCM), optical coherence tomography (OCT), line-field confocal optical coherence tomography (LC-OCT), and high-frequency ultrasound (HFUS), to enable comprehensive evaluation of skin lesions across multiple spatial scales. While dermoscopy facilitates assessment of superficial morphologic features, RCM provides near-cellular resolution imaging, C-OCT and LC-OCT offer high-resolution structural visualization at greater depths, and HFUS enables evaluation of deeper tissue architecture and lesion extent. The complementary strengths of these modalities support more accurate diagnosis, disease monitoring, and treatment assessment. This review summarizes the principles, clinical applications, advantages, and limitations of major non-invasive imaging modalities, with a particular emphasis on multimodal integration. We further propose a conceptual framework for a multimodal non-invasive skin imaging center, highlighting the roles of workflow standardization, multidisciplinary collaboration, and integrated data management. Current challenges, including implementation costs, data governance, and workforce training, are also discussed. Future developments in artificial intelligence, multicenter collaboration, and imaging-based treatment monitoring are expected to further advance precision dermatology and facilitate the broader clinical adoption of multimodal skin imaging.