The Impact of Surgical Staging on the Prognosis of Mucinous Borderline Tumors of the Ovaries: A Multicenter Study.
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Gungorduk Kemal, Asicioglu Osman, Braicu Elena Ioana, Almuheimid Jumana, Gokulu Sevki Goksun, Cetinkaya Nilufer, Gungor Tayfun, Pakay Gonca, Telli Elcin Uzmez, Cuylan Zeliha Firat, Toptas Tayfun, Bilgi Ahmet, Ozyurt Ramazan, Agacayak Elif, Ozdemir Aykut, Yildirim Nuri, Taskin Salih, Oge Tufan, Erol Onur, Akman Levent, Turan Anil, Icen Mehmet Sait, Senol Taylan, Ovali Ozlem Irak, Yucesoy Burcu, Gungorduk Ozgu, Temizkan Osman, Sanci Muzaffer, Simsek Tayup, Meydanli Mehmet Mutlu, Harma Mehmet, Yasar Levent, Uysal Aysel Derbent, Karateke Ates, Ortac Firat, Ozalp Sabit Sinan, Sehouli Jalid, Muallem Mustafa Zelal
Аннотация
PATIENTS AND METHODS: The database of 14 gynecological oncology departments from Turkey and Germany were comprehensively searched for women who underwent primary surgery for an ovarian tumor between January 1, 1998, and December 31, 2015, and whose final diagnosis was mBOT.
RESULTS: A total of 364 patients with mBOT with a median age of 43.1 years were included in this analysis. The median OS of all patients was 53.1 months. The majority of cases had Stage IA (78.6%). In univariate and multivariate analyses, radical surgery, omentectomy, appendectomy, lymphadenectomy, and adding adjuvant chemotherapy were not independent prognostic factors for PFS and OS. Furthermore, FIGO stage (≥IC vs. <IC), radical surgery, and staging surgery were not independent risk factors for recurrence of mBOTs. Finally, abnormal macroscopic appendix and FIGO stage (≥IC vs. <IC) were independent risk factors for appendiceal involvement (p=0.032).
CONCLUSION: Patients with conservative surgery do not have higher recurrence rates. Fertility-sparing surgery should be considered in the reproductive age group. Detailed surgical staging including lymphadenectomy, appendectomy, and omentectomy does not have an impact on survival rates.