La Tunisie medicale · 2016
Digestive neuroendocrine tumors: reclassifying of 26 cases according to 2010 who classification.
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Chaabane Abir, M'sakni Issam, Laabidi Basma, Bougrine Fathi, Bouziani Ammar
Аннотация
BACKGROUND: The classification of digestive neuroendocrine tumors is difficult due to their heterogeneity and rareness.
AIMS: Reclassify the digestive neuroendocrine tumors according to the WHO-2010 classification . Methods: A retrospective study included 26 patients having digestive neuroendocrine tumors , is achieved in our Pathology Laboratory of the Military Hospital of Tunis between 2000 and 2013.
RESULTS: The mean age of patients was 49.64 years. The Sex ratio was 1.36. It was 6 gastric tumors, 5 small intestine tumors , 5 pancreatic tumors, 5 appendix tumors , one hypatic tumor, one gall bladder tumor , one rectal tumor and one colon tumor. According to the WHO -2000 classification, tumors are categorised into 11 well differentiated endocrine tumors, 13 well differentiated endocrine carcinoma and 2 poorly differentiated carcinoma . According to the WHO -2010 classification, tumors were re-evaluated as 16 neuroendocrine tumors grade 1, 6 neuroendocrine tumors grade 2 and 4 neuroendocrine carcinoma .
CONCLUSION: There was a concordance between the two classifications in 93% of cases. The WHO -2010 classification may allow a better classification for the digestive neuroendocrine tumors, however there are some histological categories that remained difficult to classify.
AIMS: Reclassify the digestive neuroendocrine tumors according to the WHO-2010 classification . Methods: A retrospective study included 26 patients having digestive neuroendocrine tumors , is achieved in our Pathology Laboratory of the Military Hospital of Tunis between 2000 and 2013.
RESULTS: The mean age of patients was 49.64 years. The Sex ratio was 1.36. It was 6 gastric tumors, 5 small intestine tumors , 5 pancreatic tumors, 5 appendix tumors , one hypatic tumor, one gall bladder tumor , one rectal tumor and one colon tumor. According to the WHO -2000 classification, tumors are categorised into 11 well differentiated endocrine tumors, 13 well differentiated endocrine carcinoma and 2 poorly differentiated carcinoma . According to the WHO -2010 classification, tumors were re-evaluated as 16 neuroendocrine tumors grade 1, 6 neuroendocrine tumors grade 2 and 4 neuroendocrine carcinoma .
CONCLUSION: There was a concordance between the two classifications in 93% of cases. The WHO -2010 classification may allow a better classification for the digestive neuroendocrine tumors, however there are some histological categories that remained difficult to classify.