[NEURO-HUMORAL DISORDERS OF THE ADAPTATION SYSTEM UNDER THE ACTION OF CERTAIN CLASSES OF PESTICIDES].

This article shows the isolated and combined effects of pesticides on animals. It is known that depending on the dose and duration of exposure to various xenobiotics, the same substances, different effects can occur in the body. At the same time, the main types of combined action include the effects of summation or additive action, potentiation or synergism, as well as antagonism. From here, there may be direct or indirect disorders in humans and animals. Of great interest is the neurotoxic effect of synthetic pyrethroid insecticides, a representative of which is sumi-alpha. They have been shown to have low toxicity, but have severe neurotoxic symptoms when accumulated in the nervous system. Nicotine is one of the main toxic components of tobacco (tobacco dust). The influence of chlorinated tenoxtitlan, which include herbicide lontrel on the organism of warm-blooded animals and humans are not yet fully understood. The study found that when intoxicated with herbicides of this group, there is a decrease in the level of metabolic processes, a violation of the functions of the endocrine glands (primarily the adrenal cortex and thyroid gland) and the nervous system. Taking into account the above, and also taking into account the lack of information about the effect of a complex of pesticides on the adaptive function of the body, this study showed that in the case of combined poisoning of animals, additivity took place.