Current opinion in oncology · 2009
Genetic lesions in chronic lymphocytic leukemia: clinical implications.
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Montserrat Emili, Moreno Carol
Аннотация
PURPOSE OF REVIEW: To analyze recent scientific contributions correlating genetic lesions with clinical features in chronic lymphocytic leukemia (CLL).
RECENT FINDINGS: Genetic abnormalities are increasingly important to understand not only CLL biology but also other aspects such as its epidemiology, diagnosis, prognosis, and clinical evolution.
SUMMARY: Genetic abnormalities provide important clues in understanding the clinical and biologic heterogeneity of CLL, assessing the individual risk of each patient with this form of leukemia and also predicting response to therapy.
RECENT FINDINGS: Genetic abnormalities are increasingly important to understand not only CLL biology but also other aspects such as its epidemiology, diagnosis, prognosis, and clinical evolution.
SUMMARY: Genetic abnormalities provide important clues in understanding the clinical and biologic heterogeneity of CLL, assessing the individual risk of each patient with this form of leukemia and also predicting response to therapy.