Radiology · 1994
Early-stage glottic carcinomas: effect of tumor location and full-length involvement on local tumor recurrence after radiation therapy.
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Shimm D S
Аннотация
PURPOSE: To correlate tumor location along the vocal cord with local control in stage I and II glottic carcinoma.
MATERIALS AND METHODS: Sixty-five patients with stage I and 18 patients with stage II glottic cancer were irradiated with 4-MV x rays. Most patients received a total of 64-66 Gy, at a dose of 1.8-2.0 Gy/d.
RESULTS: In stage I tumors, local-control probability was 96% +/- 2 (standard deviation); in stage II tumors, 67% +/- 15. When stages I and II were considered together, tumors that involved the full length of the vocal cord were more likely to recur (P = .069). In stage I tumors, treatment with < 2.0 Gy/d was statistically significantly (P = .038) associated with local recurrence.
CONCLUSION: Poor outcome after irradiation could not be predicted with involvement of either the anterior commissure or posterior third of the vocal cord. Risk of tumor recurrence increased with full-length involvement, and in stage I tumors, with a daily fraction < 2.0 Gy.
MATERIALS AND METHODS: Sixty-five patients with stage I and 18 patients with stage II glottic cancer were irradiated with 4-MV x rays. Most patients received a total of 64-66 Gy, at a dose of 1.8-2.0 Gy/d.
RESULTS: In stage I tumors, local-control probability was 96% +/- 2 (standard deviation); in stage II tumors, 67% +/- 15. When stages I and II were considered together, tumors that involved the full length of the vocal cord were more likely to recur (P = .069). In stage I tumors, treatment with < 2.0 Gy/d was statistically significantly (P = .038) associated with local recurrence.
CONCLUSION: Poor outcome after irradiation could not be predicted with involvement of either the anterior commissure or posterior third of the vocal cord. Risk of tumor recurrence increased with full-length involvement, and in stage I tumors, with a daily fraction < 2.0 Gy.