Journal of fungi (Basel, Switzerland) · 2026
Localized Cutaneous Versus Deep Sporotrichosis at Hospital das Clínicas, UFMG, Belo Horizonte, Brazil: A Cohort of 213 Culture-Confirmed Cases, 2011 to 2026.
СтатьяНазвание и аннотация: Перевод в очереди
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Duani Helena, Amâncio Frederico Figueiredo, Bifano Alexandre Soares, Mattos Vitória Baltazar, Silva Kaique Veloso, Melo Beatriz Vieira, Pascoal Heloisa Filipe, Sendin Rafael Lima, Akerman Marcus Vinicius Carvalho, Thiemann Felipe Torreão Corrêa, Gonçalves Giulia Bravim, de Rezende Adriana Cristina Camargos, da Silva Leandro Cesar, Liu Shinfay Maximilian, Fonseca Marise Oliveira
Аннотация
BACKGROUND: The zoonotic epidemic of sporotrichosis caused by Sporothrix brasiliensis has expanded throughout Brazil and other countries, with a rise in deep forms of disease. Detailed comparative data on the presentation, treatment and outcomes of cutaneous and deep disease are needed to follow how Brazilian cohorts are evolving.
METHODS: The study involves a retrospective observational cohort of patients with sporotrichosis treated at a quaternary university hospital in Belo Horizonte between 2011 and 2026, restricted to culture-positive cases. Localized cutaneous disease was compared with deep infection using logistic regression adjusted for age and sex.
RESULTS: Of 313 patients, 213 had a positive culture. The median age was 41 years, and 54.0% were women. Lymphocutaneous disease predominated (54.0%), and contact with cats was reported by 53.1%. The median treatment duration was 150 days. Among the 101 patients with a defined outcome, 97 were cured (96.0%), with no documented treatment failure. All four sporotrichosis-related deaths occurred in the deep infection group, which was independently associated with comorbidity (OR 9.69; 95% CI 2.52 to 37.23) and an immunosuppressive condition (OR 6.61; 95% CI 1.89 to 23.09).
CONCLUSIONS: Localized cutaneous sporotrichosis was cured in nearly all the patients with documented follow-up, whereas mortality was confined to deep infection associated with comorbidities and immunosuppression.
METHODS: The study involves a retrospective observational cohort of patients with sporotrichosis treated at a quaternary university hospital in Belo Horizonte between 2011 and 2026, restricted to culture-positive cases. Localized cutaneous disease was compared with deep infection using logistic regression adjusted for age and sex.
RESULTS: Of 313 patients, 213 had a positive culture. The median age was 41 years, and 54.0% were women. Lymphocutaneous disease predominated (54.0%), and contact with cats was reported by 53.1%. The median treatment duration was 150 days. Among the 101 patients with a defined outcome, 97 were cured (96.0%), with no documented treatment failure. All four sporotrichosis-related deaths occurred in the deep infection group, which was independently associated with comorbidity (OR 9.69; 95% CI 2.52 to 37.23) and an immunosuppressive condition (OR 6.61; 95% CI 1.89 to 23.09).
CONCLUSIONS: Localized cutaneous sporotrichosis was cured in nearly all the patients with documented follow-up, whereas mortality was confined to deep infection associated with comorbidities and immunosuppression.