European journal of gynaecological oncology · 2017
Expressions of H2AX in cervical squamous carcinoma and their clinical significances.
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Ruan J Y, Zhu Q, Mei L, Wang H
Аннотация
OBJECTIVE: To evaluate the expression and clinical significance of H2AX in cervical squamous carcinoma.
MATERIALS AND METHODS: The expression of H2AX in the cervical squamous carcinoma of 37 patients and in the normal cervical tissue of 15 patients was detected by immuneohistochemical method. Chi-square, correlation analysis, and Kaplan-Meier were utilized to analyze the data.
RESULTS: The positive expression rate of H2AX in cervical squamous carcinoma was higher than that in normal cervical tissues (p = 0.016) . The expression of H2AX was negatively correlated with FIGO staging, vaginal invasion, and parametrial infiltration (p < 0.05). Survival analysis showed the expression intensity of H2AX had no significant effect on the prognosis.
CONCLUSION: H2AX was an anticancer protein for cervical squamous carcinoma.
MATERIALS AND METHODS: The expression of H2AX in the cervical squamous carcinoma of 37 patients and in the normal cervical tissue of 15 patients was detected by immuneohistochemical method. Chi-square, correlation analysis, and Kaplan-Meier were utilized to analyze the data.
RESULTS: The positive expression rate of H2AX in cervical squamous carcinoma was higher than that in normal cervical tissues (p = 0.016) . The expression of H2AX was negatively correlated with FIGO staging, vaginal invasion, and parametrial infiltration (p < 0.05). Survival analysis showed the expression intensity of H2AX had no significant effect on the prognosis.
CONCLUSION: H2AX was an anticancer protein for cervical squamous carcinoma.