Медицинская библиотека · European journal of gynaecological oncology · 2017

Expressions of H2AX in cervical squamous carcinoma and their clinical significances.

Ruan J Y, Zhu Q, Mei L, Wang H

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Аннотация

OBJECTIVE

To evaluate the expression and clinical significance of H2AX in cervical squamous carcinoma.

MATERIALS AND

METHODS

The expression of H2AX in the cervical squamous carcinoma of 37 patients and in the normal cervical tissue of 15 patients was detected by immuneohistochemical method. Chi-square, correlation analysis, and Kaplan-Meier were utilized to analyze the data.

RESULTS

The positive expression rate of H2AX in cervical squamous carcinoma was higher than that in normal cervical tissues (p = 0.016) . The expression of H2AX was negatively correlated with FIGO staging, vaginal invasion, and parametrial infiltration (p < 0.05). Survival analysis showed the expression intensity of H2AX had no significant effect on the prognosis.

CONCLUSION

H2AX was an anticancer protein for cervical squamous carcinoma.

Для цитирования: Ruan J Y, Zhu Q, Mei L, Wang H. Expressions of H2AX in cervical squamous carcinoma and their clinical significances.. European journal of gynaecological oncology. 2017.

Предметные рубрики MeSH

Adult Carcinoma, Squamous Cell Case-Control Studies Female Histones Humans Middle Aged Neoplasm Invasiveness Survival Rate Uterine Cervical Neoplasms

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