Early events in the suppression of myeloid leukemic cells by biological regulators.

Differentiation of mouse and human myeloid leukemic cells in vitro can be induced by some members of the granulocytemacrophage family of colony-stimulating factors. In the mouse, the most active molecule (G-CSF) is able to suppress leukemic stem cell self-generation in an irreversible, asymmetric process, suggesting that the factor permanently modifies newly synthesized one or more daughter chromatids in dividing leukemic stem cells.