Endometrial factor testing is a useful tool in clinical infertility management.

Progress in medicine depends on new technologies and countercurrent concepts that translate to practice to solve long-standing problems. The application of transcriptomics to endometrial biology enables an objective identification of the personalized period during which the maternal endometrium is receptive to an embryo, known as the window of implantation. Likewise, 16S rRNA gene sequencing of microorganisms allows the identification of commensal microbes colonizing the endometrium, linking their composition with reproductive outcomes in patients undergoing IVF. Together, this knowledge underscores the clinical implication of endometrial factor testing for personalizing reproductive care. With such exciting developments and more to come, the era of generalized medicine for the endometrial factor will come to an end and will be replaced by individualized care to improve outcomes.