Canadian respiratory journal · 2017
Risk Factors of Mortality from All Asbestos-Related Diseases: A Competing Risk Analysis.
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Abós-Herràndiz Rafael, Rodriguez-Blanco Teresa, Garcia-Allas Isabel, Rosell-Murphy Isabel-Magdalena, Albertí-Casas Constança, Tarrés Josep, Krier-Günther Illona, Martinez-Artés Xavier, Orriols Ramon, Grimau-Malet Isidre, Canela-Soler Jaume
Аннотация
BACKGROUND: The mortality from all malignant and nonmalignant asbestos-related diseases remains unknown. The authors assessed the incidence and risk factors for all asbestos-related deaths.
METHODS: The sample included 544 patients from an asbestos-exposed community in the area of Barcelona (Spain), between Jan 1, 1970, and Dec 31, 2006. Competing risk regression through a subdistribution hazard analysis was used to estimate risk factors for the outcomes.
RESULTS: Asbestos-related deaths were observed in 167 (30.7%) patients and 57.5% of these deaths were caused by some type of mesothelioma. The incidence rate after diagnosis was 3,600 per 100,000 person-years. In 7.5% of patients death was non-asbestos-related, while pleural and peritoneal mesothelioma were identified in 87 (16.0%) and 18 (3.3%) patients, respectively.
CONCLUSIONS: Age, sex, household exposure, cumulative nonmalignant asbestos-related disease, and single malignant pathology were identified as risk factors for asbestos-related death. These findings suggest the need to develop a preventive approach to the community and to improve the clinical follow-up process of these patients.
METHODS: The sample included 544 patients from an asbestos-exposed community in the area of Barcelona (Spain), between Jan 1, 1970, and Dec 31, 2006. Competing risk regression through a subdistribution hazard analysis was used to estimate risk factors for the outcomes.
RESULTS: Asbestos-related deaths were observed in 167 (30.7%) patients and 57.5% of these deaths were caused by some type of mesothelioma. The incidence rate after diagnosis was 3,600 per 100,000 person-years. In 7.5% of patients death was non-asbestos-related, while pleural and peritoneal mesothelioma were identified in 87 (16.0%) and 18 (3.3%) patients, respectively.
CONCLUSIONS: Age, sex, household exposure, cumulative nonmalignant asbestos-related disease, and single malignant pathology were identified as risk factors for asbestos-related death. These findings suggest the need to develop a preventive approach to the community and to improve the clinical follow-up process of these patients.
Предметные рубрики MeSH
Age FactorsAgedAged, 80 and overAsbestosAsbestosisCohort StudiesEnvironmental ExposureFemaleHumansIncidenceLung NeoplasmsMaleMesotheliomaMiddle AgedMortalityOccupational DiseasesOccupational ExposurePeritoneal NeoplasmsPleural NeoplasmsProportional Hazards ModelsRetrospective StudiesRisk AssessmentRisk FactorsSex FactorsSmokingSpain