The Journal of the American Association of Gynecologic Laparoscopists · 2002
Intratubal methotrexate for prevention of persistent ectopic pregnancy after salpingotomy.
Клиническое исследованиеСтатьяРандомизированное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Kaya Hakan, Babar Yasemin, Ozmen Sadik, Ozkaya Okan, Karci Mehmet, Aydin Ali Riza, Ozbasar Demir
Аннотация
STUDY OBJECTIVE: To investigate whether frequency of persistent ectopic pregnancy after linear salpingotomy can be reduced by prophylactic administration of a single intraoperative injection of local methotrexate.
DESIGN: Prospective, randomized, controlled trial (Canadian Task Force classification I).
SETTING: University-affiliated hospital.
PATIENTS: Sixty-five women with unruptured ectopic pregnancy.
INTERVENTION: Laparoscopic salpingotomy with or without a single intratubal dose of methotrexate 1 mg/kg.
MEASUREMENTS AND MAIN RESULTS: In the prophylaxis group, 22 patients received a single dose of intratubal methotrexate 1 mg/kg after linear salpingotomy; 43 controls had only linear salpingotomy. Six women (14%) in the control group developed persistent ectopic pregnancy, compared with none in the prophylaxis group (p <0.05).
CONCLUSION: In our opinion, intratubal methotrexate injection during laparoscopic salpingotomy is a practical option for women with unruptured ectopic pregnancy.
DESIGN: Prospective, randomized, controlled trial (Canadian Task Force classification I).
SETTING: University-affiliated hospital.
PATIENTS: Sixty-five women with unruptured ectopic pregnancy.
INTERVENTION: Laparoscopic salpingotomy with or without a single intratubal dose of methotrexate 1 mg/kg.
MEASUREMENTS AND MAIN RESULTS: In the prophylaxis group, 22 patients received a single dose of intratubal methotrexate 1 mg/kg after linear salpingotomy; 43 controls had only linear salpingotomy. Six women (14%) in the control group developed persistent ectopic pregnancy, compared with none in the prophylaxis group (p <0.05).
CONCLUSION: In our opinion, intratubal methotrexate injection during laparoscopic salpingotomy is a practical option for women with unruptured ectopic pregnancy.
Предметные рубрики MeSH
Abortifacient Agents, NonsteroidalAdultCombined Modality TherapyFallopian Tube Patency TestsFallopian TubesFemaleFollow-Up StudiesHumansInjections, IntralesionalMethotrexatePregnancyPregnancy, EctopicPregnancy, TubalPrimary PreventionProspective StudiesReference ValuesSalpingostomySecondary PreventionTreatment Outcome