European journal of obstetrics, gynecology, and reproductive biology · 2005
The effect of a nicorandil congener on isolated human myometrium.
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Parimala K, Peedicayil Jacob, Peedicayil Abraham, Nelson Nissy, Ernest Kalpana
Аннотация
OBJECTIVE: To determine the effect of a nicorandil congener, SG-209 on the myometrium.
STUDY DESIGN: Isolated strips of myometrium, from nine women who underwent hysterectomy, were made to contract with 55 mM KCl before and after incubation with three concentrations of SG-209 (1.5, 3.0 and 10 microM). The mean height of contraction and the area under the curve were analysed using a non-parametric test.
RESULTS: At a 10 microM concentration, SG-209 significantly decreased the mean area under the curve from 10.8 to 2.5 cm2 (p<0.05).
CONCLUSION: SG-209 significantly relaxes the human non-pregnant myometrium. Along with its congener, nicorandil, it may be useful in clinical conditions that require uterine relaxation.
STUDY DESIGN: Isolated strips of myometrium, from nine women who underwent hysterectomy, were made to contract with 55 mM KCl before and after incubation with three concentrations of SG-209 (1.5, 3.0 and 10 microM). The mean height of contraction and the area under the curve were analysed using a non-parametric test.
RESULTS: At a 10 microM concentration, SG-209 significantly decreased the mean area under the curve from 10.8 to 2.5 cm2 (p<0.05).
CONCLUSION: SG-209 significantly relaxes the human non-pregnant myometrium. Along with its congener, nicorandil, it may be useful in clinical conditions that require uterine relaxation.