Медицинская библиотека · Science (New York, N.Y.) · 2022
Local connectivity and synaptic dynamics in mouse and human neocortex.
Campagnola Luke, Seeman Stephanie C, Chartrand Thomas, Kim Lisa, Hoggarth Alex, Gamlin Clare, Ito Shinya, Trinh Jessica, Davoudian Pasha, Radaelli Cristina, Kim Mean-Hwan, Hage Travis, Braun Thomas, Alfiler Lauren, Andrade Julia, Bohn Phillip, Dalley Rachel, Henry Alex, Kebede Sara, Alice Mukora, Sandman David, Williams Grace, Larsen Rachael, Teeter Corinne, Daigle Tanya L, Berry Kyla, Dotson Nadia, Enstrom Rachel, Gorham Melissa, Hupp Madie, Dingman Lee Samuel, Ngo Kiet, Nicovich Philip R, Potekhina Lydia, Ransford Shea, Gary Amanda, Goldy Jeff, McMillen Delissa, Pham Trangthanh, Tieu Michael, Siverts La'Akea, Walker Miranda, Farrell Colin, Schroedter Martin, Slaughterbeck Cliff, Cobb Charles, Ellenbogen Richard, Gwinn Ryder P, Keene C Dirk, Ko Andrew L, Ojemann Jeffrey G, Silbergeld Daniel L, Carey Daniel, Casper Tamara, Crichton Kirsten, Clark Michael, Dee Nick, Ellingwood Lauren, Gloe Jessica, Kroll Matthew, Sulc Josef, Tung Herman, Wadhwani Katherine, Brouner Krissy, Egdorf Tom, Maxwell Michelle, McGraw Medea, Pom Christina Alice, Ruiz Augustin, Bomben Jasmine, Feng David, Hejazinia Nika, Shi Shu, Szafer Aaron, Wakeman Wayne, Phillips John, Bernard Amy, Esposito Luke, D'Orazi Florence D, Sunkin Susan, Smith Kimberly, Tasic Bosiljka, Arkhipov Anton, Sorensen Staci, Lein Ed, Koch Christof, Murphy Gabe, Zeng Hongkui, Jarsky Tim
СтатьяПоддержка NIH: внешняя программаПеревод пока не подготовлен
Аннотация
We present a unique, extensive, and open synaptic physiology analysis platform and dataset. Through its application, we reveal principles that relate cell type to synaptic properties and intralaminar circuit organization in the mouse and human cortex. The dynamics of excitatory synapses align with the postsynaptic cell subclass, whereas inhibitory synapse dynamics partly align with presynaptic cell subclass but with considerable overlap. Synaptic properties are heterogeneous in most subclass-to-subclass connections. The two main axes of heterogeneity are strength and variability. Cell subclasses divide along the variability axis, whereas the strength axis accounts for substantial heterogeneity within the subclass. In the human cortex, excitatory-to-excitatory synaptic dynamics are distinct from those in the mouse cortex and vary with depth across layers 2 and 3.
Для цитирования: Campagnola Luke, Seeman Stephanie C, Chartrand Thomas, Kim Lisa, Hoggarth Alex, Gamlin Clare, Ito Shinya, Trinh Jessica, Davoudian Pasha, Radaelli Cristina, Kim Mean-Hwan, Hage Travis, Braun Thomas, Alfiler Lauren, Andrade Julia, Bohn Phillip, Dalley Rachel, Henry Alex, Kebede Sara, Alice Mukora, Sandman David, Williams Grace, Larsen Rachael, Teeter Corinne, Daigle Tanya L, Berry Kyla, Dotson Nadia, Enstrom Rachel, Gorham Melissa, Hupp Madie, Dingman Lee Samuel, Ngo Kiet, Nicovich Philip R, Potekhina Lydia, Ransford Shea, Gary Amanda, Goldy Jeff, McMillen Delissa, Pham Trangthanh, Tieu Michael, Siverts La'Akea, Walker Miranda, Farrell Colin, Schroedter Martin, Slaughterbeck Cliff, Cobb Charles, Ellenbogen Richard, Gwinn Ryder P, Keene C Dirk, Ko Andrew L, Ojemann Jeffrey G, Silbergeld Daniel L, Carey Daniel, Casper Tamara, Crichton Kirsten, Clark Michael, Dee Nick, Ellingwood Lauren, Gloe Jessica, Kroll Matthew, Sulc Josef, Tung Herman, Wadhwani Katherine, Brouner Krissy, Egdorf Tom, Maxwell Michelle, McGraw Medea, Pom Christina Alice, Ruiz Augustin, Bomben Jasmine, Feng David, Hejazinia Nika, Shi Shu, Szafer Aaron, Wakeman Wayne, Phillips John, Bernard Amy, Esposito Luke, D'Orazi Florence D, Sunkin Susan, Smith Kimberly, Tasic Bosiljka, Arkhipov Anton, Sorensen Staci, Lein Ed, Koch Christof, Murphy Gabe, Zeng Hongkui, Jarsky Tim. Local connectivity and synaptic dynamics in mouse and human neocortex.. Science (New York, N.Y.). 2022. DOI: 10.1126/science.abj5861.
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