American journal of translational research · 2025
Therapeutic effects of transverse tibial bone transport in lower limb thromboangiitis obliterans.
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Hong Minyou, Jin Qi
Аннотация
OBJECTIVE: To investigate the treatment efficacy of transverse tibial bone transport (TTT) technique in patients with lower-limb thromboangiitis obliterans (LLTAO).
METHODS: A total of 119 patients diagnosed with LLTAO were selected for this retrospective study. Among them, 55 patients treated with conventional methods were assigned into the control group, while the other 64 patients treated with TTT technique were classified into the observation group. Systematic comparative evaluations were conducted between the two patient cohorts, analyzing four key domains: clinical recovery, hemorheological profile alterations, quality of life metrics, and treatment efficacy. Furthermore, we performed an exploratory analysis to identify determinants affecting therapeutic outcome.
RESULTS: The observation group showed significantly better outcomes than the control group in terms of functional recovery, hemorheological improvement, quality of life scores, and overall treatment effectiveness following the intervention. Univariate and multivariate analyses further demonstrated that age, pretreatment HBV, and treatment approach were all independent factors influencing treatment efficacy in these patients.
CONCLUSION: The TTT technique exhibits superior therapeutic benefits for LLTAO patients over conventional intervention, establishing it as an effective treatment for this challenging condition.
METHODS: A total of 119 patients diagnosed with LLTAO were selected for this retrospective study. Among them, 55 patients treated with conventional methods were assigned into the control group, while the other 64 patients treated with TTT technique were classified into the observation group. Systematic comparative evaluations were conducted between the two patient cohorts, analyzing four key domains: clinical recovery, hemorheological profile alterations, quality of life metrics, and treatment efficacy. Furthermore, we performed an exploratory analysis to identify determinants affecting therapeutic outcome.
RESULTS: The observation group showed significantly better outcomes than the control group in terms of functional recovery, hemorheological improvement, quality of life scores, and overall treatment effectiveness following the intervention. Univariate and multivariate analyses further demonstrated that age, pretreatment HBV, and treatment approach were all independent factors influencing treatment efficacy in these patients.
CONCLUSION: The TTT technique exhibits superior therapeutic benefits for LLTAO patients over conventional intervention, establishing it as an effective treatment for this challenging condition.