The Laryngoscope · 2016
A validated method of labial minor salivary gland biopsy for the diagnosis of Sjögren's syndrome.
СтатьяВалидационное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Kim Jean, Sun Daniel, Ozl Rebecca, Grader-Beck Thomas, Birnbaum Julius, Akpek Esen K, Baer Alan N
Аннотация
OBJECTIVES/HYPOTHESIS: To validate a technique and outcomes of labial minor salivary gland biopsy (LSGB) used for the diagnosis of Sjögren's syndrome (SS).
STUDY DESIGN: Prospective cohort study.
METHODS: Clinical data were prospectively obtained pre- and postbiopsy using patient-reported questionnaires. LSGB was performed using described methods. Specimens were analyzed by a pathologist with expertise in SS and assessed using established criteria to determine the focus score. Data were analyzed using cross-tabulations.
RESULTS: Among the 58 patients in the study, 52 (90%) presented with sicca symptoms of dry eyes and/or mouth. Eight patients (14%) had histopathologic findings supportive of a diagnosis of SS. At 1 month postbiopsy, greater than 71% of patients denied any complaints of pain, swelling, numbness. or tingling. Sixteen patients (28%) had only a minor level of complaints. Only one patient complained of severe numbness at the biopsy site. Greater than 70% of patients would consider rebiopsy after the procedure, if requested by their physician.
CONCLUSIONS: We present a safe and effective method of LSGB for the diagnosis of SS.
LEVEL OF EVIDENCE: 4 Laryngoscope, 126:2041-2046, 2016.
STUDY DESIGN: Prospective cohort study.
METHODS: Clinical data were prospectively obtained pre- and postbiopsy using patient-reported questionnaires. LSGB was performed using described methods. Specimens were analyzed by a pathologist with expertise in SS and assessed using established criteria to determine the focus score. Data were analyzed using cross-tabulations.
RESULTS: Among the 58 patients in the study, 52 (90%) presented with sicca symptoms of dry eyes and/or mouth. Eight patients (14%) had histopathologic findings supportive of a diagnosis of SS. At 1 month postbiopsy, greater than 71% of patients denied any complaints of pain, swelling, numbness. or tingling. Sixteen patients (28%) had only a minor level of complaints. Only one patient complained of severe numbness at the biopsy site. Greater than 70% of patients would consider rebiopsy after the procedure, if requested by their physician.
CONCLUSIONS: We present a safe and effective method of LSGB for the diagnosis of SS.
LEVEL OF EVIDENCE: 4 Laryngoscope, 126:2041-2046, 2016.