Asian Pacific journal of cancer prevention : APJCP · 2012
Comparison of two ovarian malignancy prediction models based on age sonographic findings and serum CA125 measurement.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Arab Maliheh, Yaseri Mehdi, Ashrafganjoi Tahereh, Maktabi Maryam, Noghabaee Giti, Sheibani Kourosh
Аннотация
OBJECTIVE: The aim of our study is to compare an ovarian malignancy prediction model based on age and four sonographic findings (OMPS1) with a new model called OMPS2 which differs just by adding serum CA125 measurement to (OMPS1).
METHODS: In a cross sectional comparative study OMPS1 was validated in 830 operated ovarian masses within a 3 years period (2006-2009). Logistic regression analysis was used to construct OMPS2 based on OMPS1 adding serum CA125 findings. The area under the curve for two models was compared in 411 patients.
RESULTS: OMPS2 was calculated as follows: OMPS1 + 1.444 (if serum CA125= 36-200) or 3.842 (if serum CA125 is more than 200). AUC of OMPS2 was increased to 84.3% (CI 95% 78.1- 89.8) in comparison to OMPS1 with AUC of 78.1% (CI 95% 71.8-84.5).
CONCLUSION: Our second model is more accurate in prediction of ovarian malignancy, compared with our first model.
METHODS: In a cross sectional comparative study OMPS1 was validated in 830 operated ovarian masses within a 3 years period (2006-2009). Logistic regression analysis was used to construct OMPS2 based on OMPS1 adding serum CA125 findings. The area under the curve for two models was compared in 411 patients.
RESULTS: OMPS2 was calculated as follows: OMPS1 + 1.444 (if serum CA125= 36-200) or 3.842 (if serum CA125 is more than 200). AUC of OMPS2 was increased to 84.3% (CI 95% 78.1- 89.8) in comparison to OMPS1 with AUC of 78.1% (CI 95% 71.8-84.5).
CONCLUSION: Our second model is more accurate in prediction of ovarian malignancy, compared with our first model.