Bioorganic & medicinal chemistry letters · 2020
Novel dual LSD1/HDAC6 inhibitors for the treatment of multiple myeloma.
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Naveen Sadhu M, Sivanandhan Dhanalakshmi, Gajendran Chandru, Tantry Subramanyam, Dewang Purushottam, Murugan Kannan, Chickamunivenkatappa Srinatha, Zainuddin Mohd, Nair Sreekala, Vaithilingam Krishnakumar, Rajagopal Sridharan
Аннотация
Lysine specific demethylase 1 (LSD1) and HDAC6 are epigenetic proteins associated with several diseases, including cancer and combined inhibition of these proteins could be highly beneficial in treating some cancers such as AML, MM and solid tumors. Multiple myeloma (MM) is a challenging cancer with fast relapse rate where novel treatment options are the need of the hour. We have designed and developed novel, LSD1 and HDAC6 selective dual inhibitors to target MM. Our dual inhibitor compound 1 shows superior potency in multiple MM cell lines. In MM.1S xenograft model compound 1 shows superior efficacy compared to single agent LSD1 and HDAC6 inhibitors by oral administration and is well tolerated. Further evaluation of the molecule in other cancers is in progress.