Annals of nuclear medicine · 2015
Validity of the mediastinum as a reference region to evaluate cardiac accumulation of iodine-123 metaiodobenzylguanidine.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Inoue Yusuke, Abe Yutaka, Asano Yuji, Kikuchi Kei
Аннотация
OBJECTIVE: The heart-to-mediastinum (H/M) ratio, the heart count normalized for the mediastinum count, is commonly used in cardiac (123)I-metaiodobenzylguanidine (MIBG) imaging. However, there are reports describing age-dependent increases in the mediastinum count with or without correction for the injected dose (ID) and a poor correlation between the H/M ratio and heart count normalized for ID. We evaluated the validity of the mediastinum count as a reference in comparison with the ID.
METHODS: Results of cardiac (123)I-MIBG imaging in 200 patients were analyzed. The mean counts for the heart and mediastinum were estimated to calculate the H/M ratio. Additionally, the heart and mediastinum counts were normalized for ID measured with a dose calibrator. ID was corrected for body size represented by body weight, body surface area, or lean body mass.
RESULTS: The coefficient of variance of the ID-normalized mediastinum count was reduced by correcting ID for body size. The indicators of body size showed significant negative correlations with age. Although a positive correlation was found between age and the ID-normalized mediastinum counts, the age-dependence was reduced by body size correction. There was a close correlation between the H/M ratio and ID-normalized heart counts, and body size correction improved the correlation.
CONCLUSION: The results of this study indicate the validity of the mediastinum as a reference region and support the use of the H/M ratio as an index of cardiac accumulation of (123)I-MIBG.
METHODS: Results of cardiac (123)I-MIBG imaging in 200 patients were analyzed. The mean counts for the heart and mediastinum were estimated to calculate the H/M ratio. Additionally, the heart and mediastinum counts were normalized for ID measured with a dose calibrator. ID was corrected for body size represented by body weight, body surface area, or lean body mass.
RESULTS: The coefficient of variance of the ID-normalized mediastinum count was reduced by correcting ID for body size. The indicators of body size showed significant negative correlations with age. Although a positive correlation was found between age and the ID-normalized mediastinum counts, the age-dependence was reduced by body size correction. There was a close correlation between the H/M ratio and ID-normalized heart counts, and body size correction improved the correlation.
CONCLUSION: The results of this study indicate the validity of the mediastinum as a reference region and support the use of the H/M ratio as an index of cardiac accumulation of (123)I-MIBG.