Planta medica · 2020
Diterpenoids from Leaves of Cultivated Plectranthus ornatus.
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Mesquita Lidivânia Silva Freitas, Matos Taynara Simão, Ávila Fábio do Nascimento, Batista Alison da Silva, Moura Andréa Felinto, de Moraes Manoel Odorico, da Silva Matheus Carlos Matos, Ferreira Talles Luann Abrantes, Nascimento Nilberto Robson Falcão, Monteiro Norberto Kássio Vieira, Pessoa Otília Deusdênia Loiola
Аннотация
Two new diterpenoid derivatives 7α,12β,17-triacetoxy-6β,19-dihydroxy-13β,16-spirocicloabiet-8-ene-11,14-dione ( 1: ) and 6β-acetoxy-3β,7α,12α-trihydroxy-13β,16-spirocicloabiet-8-ene-11,14-dione ( 2: ) along with 11 ( 3: - 13: ) miscellaneous compounds were isolated from the leaves of Plectranthus ornatus Codd. Their structures were elucidated by spectroscopic analysis and gauge independent atomic orbitals 13C NMR calculations. The isolated compounds were screened for their effects on intestinal motility using guinea-pig ileum and duodenum and by their cytotoxicity against 4 human cancer cell lines (HCT-116, SF-295, PC-3, and HL-60). Compounds 6: and 9: were moderately cytotoxic against HL-60, whereas 6: and 13: were more active on SF-295 and HCT-116.