Future oncology (London, England) · 2025
Prognostic value of Naples prognostic score for locally advanced gastric cancer after neoadjuvant chemoimmunotherapy.
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Sun Xiong, Ruan Tuo, Lin Yao, Li Chengguo, Shen Qian, Li Tianhao, Ding Jianing, Yin Yuping, Tao Kaixiong
Аннотация
BACKGROUND: The parameters of the Naples prognostic score (NPS) include albumin, total cholesterol, neutrophil-lymphocyte ratio, and lymphocyte-monocyte ratio. This study aimed to investigate the prognostic value of preoperative NPS in locally advanced gastric cancer(LAGC) patients underwent radical resection after neoadjuvant chemoimmunotherapy (NCIT).
RESEARCH DESIGN AND METHODS: The NPS was calculated and patients were then divided into two groups according to their NPS values as follows: NPS = 0-2 (group 1), NPS = 3-4 (group 2). Univariate and multivariate Cox analysis were used to identify independent prognostic factors associated with overall survival (OS), and time-dependent receiver operating characteristic (t-ROC) curves were carried to evaluate the discriminatory capacity of the prognostic scoring systems.
RESULTS: A total of 117 patients were included in this study. The 1- and 2-year OS rates in group 1 were 100.0% and 95.7%, group 2 exhibited rates of 95.7% and 84.4%. Multivariate cox analysis demonstrated that NPS was an independent prognostic factor of OS (p = 0.009). Furthermore, NPS exhibited better prognostic performance in the prediction of OS than additional prognostic scoring systems.
CONCLUSIONS: NPS is a significant prognostic indicator and can be a reliable predictor of survival in LAGC patients underwent radical resection after NCIT.
RESEARCH DESIGN AND METHODS: The NPS was calculated and patients were then divided into two groups according to their NPS values as follows: NPS = 0-2 (group 1), NPS = 3-4 (group 2). Univariate and multivariate Cox analysis were used to identify independent prognostic factors associated with overall survival (OS), and time-dependent receiver operating characteristic (t-ROC) curves were carried to evaluate the discriminatory capacity of the prognostic scoring systems.
RESULTS: A total of 117 patients were included in this study. The 1- and 2-year OS rates in group 1 were 100.0% and 95.7%, group 2 exhibited rates of 95.7% and 84.4%. Multivariate cox analysis demonstrated that NPS was an independent prognostic factor of OS (p = 0.009). Furthermore, NPS exhibited better prognostic performance in the prediction of OS than additional prognostic scoring systems.
CONCLUSIONS: NPS is a significant prognostic indicator and can be a reliable predictor of survival in LAGC patients underwent radical resection after NCIT.