Inflammopharmacology · 2025
Anti-inflammatory and gastroprotective effects of Fagonia bruguieri var. laxa (Zygophyllaceae) via attenuating biochemical alterations and cellular damage in experimental animals.
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Javaid Faraza, Gul Humaira, Mukhtar Farhan, Farsi Salman, Ghafoor Sana, Arshad Hafiza Maida
Аннотация
OBJECTIVE: The current study aims to authenticate the traditional usage of Fagonia bruguieri var. laxa in eczema, ulcers, and gastrointestinal diseases.
METHODS: Fagonia bruguieri var. laxa. was collected, washed, dried, and ground, and its 70% aqueous methanolic solution was subjected to a rotary evaporator to produce the crude extract of the plant. Preliminary phytochemical screening was performed to validate the presence of secondary metabolites. The anti-inflammatory potential was assessed using the Carrageenan-induced paw edema test, and the anti-peptic ulcer activity was assessed using the Aspirin-induced gastric lesion/ulcer and Cysteamine-induced duodenal lesion/ulcer models in Wistar albino rats. At the end of the experiment, total acidity, ulcer index, biochemical markers, and histological changes were assessed.
RESULT: The crude extract of Fagonia bruguieri var. laxa. (Fb.Cr) reduced rat paw edema significantly (P < 0.001) by the fifth hour, with a maximum percent inhibition of 30.6%. In an aspirin-induced gastric lesion model, Fb.Cr was observed to improve pH, decrease overall acidity of stomach contents, and reduce ulcer index at dosages ranging from 100 to 500 mg/kg. In the Cysteamine-induced duodenal lesion model, Fb.Cr was found to reduce the severity score and ulcer index in a dose-dependent manner. The acute toxicity investigation determined that crude extract was safe up to the dose of 5 g/kg.
CONCLUSION: The current study's findings show that the crude extract of Fagonia bruguieri (Fb.Cr) has anti-inflammatory, gastric, and duodenal protective actions, which support its folkloric use in the management and treatment of inflammation and gastric disorders.
METHODS: Fagonia bruguieri var. laxa. was collected, washed, dried, and ground, and its 70% aqueous methanolic solution was subjected to a rotary evaporator to produce the crude extract of the plant. Preliminary phytochemical screening was performed to validate the presence of secondary metabolites. The anti-inflammatory potential was assessed using the Carrageenan-induced paw edema test, and the anti-peptic ulcer activity was assessed using the Aspirin-induced gastric lesion/ulcer and Cysteamine-induced duodenal lesion/ulcer models in Wistar albino rats. At the end of the experiment, total acidity, ulcer index, biochemical markers, and histological changes were assessed.
RESULT: The crude extract of Fagonia bruguieri var. laxa. (Fb.Cr) reduced rat paw edema significantly (P < 0.001) by the fifth hour, with a maximum percent inhibition of 30.6%. In an aspirin-induced gastric lesion model, Fb.Cr was observed to improve pH, decrease overall acidity of stomach contents, and reduce ulcer index at dosages ranging from 100 to 500 mg/kg. In the Cysteamine-induced duodenal lesion model, Fb.Cr was found to reduce the severity score and ulcer index in a dose-dependent manner. The acute toxicity investigation determined that crude extract was safe up to the dose of 5 g/kg.
CONCLUSION: The current study's findings show that the crude extract of Fagonia bruguieri (Fb.Cr) has anti-inflammatory, gastric, and duodenal protective actions, which support its folkloric use in the management and treatment of inflammation and gastric disorders.