Biomarkers in medicine · 2025
Upregulation of lncRNA ANRASSF1 is associated with the lymph node metastasis and H. pylori infection in gastric cancer.
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Khosroshahi Negin Sadi, Akbarzadeh Sama, Abbaslou Elaheh Malek, Rajabi Ali, Abdi Adel, Saber Ali, Pakmanesh Amir Reza, Safaralizadeh Reza
Аннотация
BACKGROUND: Gastric cancer is the fifth most common malignancy worldwide. Early diagnosis of GC can increase survival rate and treatment outcome. In the present study, the expression of lncRNA ANRASSF1 was evaluated in gastric tumor tissues.
METHODS: One hundred and two pairs of gastric tumors and non-tumor tissues were collected from Tabriz International Valiasr Hospital, Iran. RNA was extracted, followed by cDNA synthesis. Expression of ANRASSF1 was assessed using real-time PCR method.
RESULTS: ANRASSF1 was significantly overexpressed in GC (p < 0.001). We found a significant association between ANRASSF1 expression and lymph node metastasis (p = 0.014), Helicobacter pylori infection (p = 0.029), and Lauren subtypes (p = 0.0001).
CONCLUSION: LncRNA ANRASSF1 appears to have an oncogenic role in GC, and it may be regarded as a diagnosis and prognostic biomarker in patients with GC.
METHODS: One hundred and two pairs of gastric tumors and non-tumor tissues were collected from Tabriz International Valiasr Hospital, Iran. RNA was extracted, followed by cDNA synthesis. Expression of ANRASSF1 was assessed using real-time PCR method.
RESULTS: ANRASSF1 was significantly overexpressed in GC (p < 0.001). We found a significant association between ANRASSF1 expression and lymph node metastasis (p = 0.014), Helicobacter pylori infection (p = 0.029), and Lauren subtypes (p = 0.0001).
CONCLUSION: LncRNA ANRASSF1 appears to have an oncogenic role in GC, and it may be regarded as a diagnosis and prognostic biomarker in patients with GC.