Journal of medical primatology · 2013
Evaluation of the lymphocyte trafficking drug FTY720 in vaginal tissues.
СтатьяПоддержка NIH: внешняя программаПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод пока не подготовлен
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Tsuiki Ai, Luo Wei, Henning Tara, Vishwanathan Sundaram, Dinh Chuong, Adams Debra, Sweeney Elizabeth, Mitchell James, Bachman Shannon, Sharma Prachi, Powell Nathaniel, Hendry Michael, McNicholl Janet, Kersh Ellen
Аннотация
BACKGROUND: FTY720 is an immunomodulatory agent that reduces lymphocytes in peripheral tissues and circulation. Such agents may be effective as vaginal microbicides for HIV prevention. Systemic or vaginal application of FTY720 may reduce lymphocyte concentrations in genital tissues, reducing HIV target cell numbers.
METHODS: Five female pigtail macaques received topical vaginal gel FTY720 (n = 2), intravenous (i.v.) FTY720 (n = 2), or placebo gel (n = 1) in this pilot study. Circulating and mucosal lymphocytes and genital mucosa, cytokines, and tissue histology were analyzed to document topical and i.v. FTY720 effects.
RESULTS: Topical and i.v. FTY720 appeared to decrease the levels of cervicovaginal IL-8, IL-1ra, and genital inflammatory cells. Small sample size precluded statistical analysis. Topical administration had no overt adverse effects.
CONCLUSIONS: This study introduces FTY720 as an immunomodulatory agent for the vaginal mucosa, compares topical effects to those of i.v. administration, and provides the basis for future studies involving FTY720 for HIV prevention.
METHODS: Five female pigtail macaques received topical vaginal gel FTY720 (n = 2), intravenous (i.v.) FTY720 (n = 2), or placebo gel (n = 1) in this pilot study. Circulating and mucosal lymphocytes and genital mucosa, cytokines, and tissue histology were analyzed to document topical and i.v. FTY720 effects.
RESULTS: Topical and i.v. FTY720 appeared to decrease the levels of cervicovaginal IL-8, IL-1ra, and genital inflammatory cells. Small sample size precluded statistical analysis. Topical administration had no overt adverse effects.
CONCLUSIONS: This study introduces FTY720 as an immunomodulatory agent for the vaginal mucosa, compares topical effects to those of i.v. administration, and provides the basis for future studies involving FTY720 for HIV prevention.
Предметные рубрики MeSH
Administration, IntravaginalAdministration, IntravenousAnimalsAnti-Infective AgentsCervix UteriDrug Evaluation, PreclinicalFemaleFingolimod HydrochlorideHIV InfectionsImmunosuppressive AgentsInterleukin 1 Receptor Antagonist ProteinInterleukin-8Lymphocyte CountMacaca nemestrinaMucous MembranePilot ProjectsPlacebosPropylene GlycolsSphingosineVaginaVaginal Creams, Foams, and Jellies