Retina (Philadelphia, Pa.) · 2025
Incidence of Visual Loss in Patients with Diabetic Macular Ischemia (DMI) A 1- year Prospective Study.
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Gilead Noa, Chong Yu Jeat, Yamaguchi Taffeta C N, Chan Hiok Hong, Fenner Beau J, Ibrahim Farah I, Sun Christopher, Sivaprasad Sobha, Gemmy Cheung Chui Ming
Аннотация
PURPOSE: To report on the 1-year incidence and risk factors of visual loss in patients with diabetic macular ischemia.
METHODS: Prospective, observational cohort. Patients had stable panretinal photocoagulation treated eyes for either proliferative diabetic retinopathy or severe non-proliferative diabetic retinopathy. Main outcomes measures: best corrected visual acuity (BCVA) and low luminance visual acuity (LLVA). Optical coherence tomography (OCT), OCT angiography (OCTA), and retinal sensitivity were recorded at baseline and week 52.
RESULTS: The cohort included 53 patients and 66 eyes. The mean (SD) age was 57.9 (10.6) years, with a mean (SD) diabetes duration of 17.9 (11.0) years. 40.4% of eyes lost ≥5 BCVA and/or LLVA letters. Disorganization of retinal layers (DRIL) was observed in 71.4% of eyes with vision loss compared to 38.7% of eyes without vision loss, odds ratio=3.96 (95% CI, 1.25 to 13.84, P=0.02). Baseline deep vascular density and superficial vascular density correlated positively with week 52 BCVA (rho=0.32, 95% CI: -0.02 to 0.59; P=0.05) and week 52 LLVA (rho=0.33, 95% CI -0.02 to 0.61; P=0.04) respectively.
CONCLUSION: DRIL was associated with vision loss, and baseline OCTA vascular parameters positively predicted VA outcomes.
METHODS: Prospective, observational cohort. Patients had stable panretinal photocoagulation treated eyes for either proliferative diabetic retinopathy or severe non-proliferative diabetic retinopathy. Main outcomes measures: best corrected visual acuity (BCVA) and low luminance visual acuity (LLVA). Optical coherence tomography (OCT), OCT angiography (OCTA), and retinal sensitivity were recorded at baseline and week 52.
RESULTS: The cohort included 53 patients and 66 eyes. The mean (SD) age was 57.9 (10.6) years, with a mean (SD) diabetes duration of 17.9 (11.0) years. 40.4% of eyes lost ≥5 BCVA and/or LLVA letters. Disorganization of retinal layers (DRIL) was observed in 71.4% of eyes with vision loss compared to 38.7% of eyes without vision loss, odds ratio=3.96 (95% CI, 1.25 to 13.84, P=0.02). Baseline deep vascular density and superficial vascular density correlated positively with week 52 BCVA (rho=0.32, 95% CI: -0.02 to 0.59; P=0.05) and week 52 LLVA (rho=0.33, 95% CI -0.02 to 0.61; P=0.04) respectively.
CONCLUSION: DRIL was associated with vision loss, and baseline OCTA vascular parameters positively predicted VA outcomes.