Nature communications · 2023
Noninvasive electromyometrial imaging of human uterine maturation during term labor.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Wang Hui, Wen Zichao, Wu Wenjie, Sun Zhexian, Kisrieva-Ware Zulfia, Lin Yiqi, Wang Sicheng, Gao Hansong, Xu Haonan, Zhao Peinan, Wang Qing, Macones George A, Schwartz Alan L, Cuculich Phillip, Cahill Alison G, Wang Yong
Аннотация
Electromyometrial imaging (EMMI) was recently developed to image the three-dimensional (3D) uterine electrical activation during contractions noninvasively and accurately in sheep. Herein we describe the development and application of a human EMMI system to image and evaluate 3D uterine electrical activation patterns at high spatial and temporal resolution during human term labor. We demonstrate the successful integration of the human EMMI system during subjects' clinical visits to generate noninvasively the uterine surface electrical potential maps, electrograms, and activation sequence through an inverse solution using up to 192 electrodes distributed around the abdomen surface. Quantitative indices, including the uterine activation curve, are developed and defined to characterize uterine surface contraction patterns. We thus show that the human EMMI system can provide detailed 3D images and quantification of uterine contractions as well as novel insights into the role of human uterine maturation during labor progression.