Non-neovascular age-related macular degeneration with subretinal fluid.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Hilely Assaf, Au Adrian, Freund K Bailey, Loewenstein Anat, Souied Eric H, Zur Dinah, Sacconi Riccardo, Borrelli Enrico, Peiretti Enrico, Iovino Claudio, Sugiura Yoshimi, Ellabban Abdallah A, Monés Jordi, Waheed Nadia K, Ozdek Sengul, Yalinbas Duygu, Thiele Sarah, de Moura Mendonça Luísa Salles, Lee Mee Yon, Lee Won Ki, Turcotte Pierre, Capuano Vittorio, Filali Ansary Meryem, Chakravarthy Usha, Lommatzsch Albrecht, Gunnemann Frederic, Pauleikhoff Daniel, Ip Michael S, Querques Giuseppe, Holz Frank G, Spaide Richard F, Sadda SriniVas, Sarraf David
Аннотация
METHODS: This retrospective study included only eyes with non-neovascular AMD and associated SRF. Eyes with evidence of MNV were excluded. Spectral-domain optical coherence tomography (SD-OCT) was obtained at baseline and at follow-up, and qualitative and quantitative SD-OCT analysis of macular drusen including drusenoid pigment epithelial detachment (PED) and associated SRF was performed to determine anatomic outcomes.
RESULTS: Forty-five eyes (45 patients) were included in this analysis. Mean duration of follow-up was 49.7±36.7 months. SRF exhibited three different morphologies: crest of fluid over the apex of the drusenoid PED, pocket of fluid at the angle of a large druse or in the crypt of confluent drusen or drape of low-lying fluid over confluent drusen. Twenty-seven (60%) of the 45 eyes with fluid displayed collapse of the associated druse or drusenoid PED and 24 (53%) of the 45 eyes developed evidence of complete or incomplete retinal pigment epithelial and outer retinal atrophy.
CONCLUSION: Non-neovascular AMD with SRF is an important clinical entity to recognise to avoid unnecessary anti-vascular endothelial growth factor therapy. Clinicians should be aware that SRF can be associated with drusen or drusenoid PED in the absence of MNV and may be the result of retinal pigment epithelial (RPE) decompensation and RPE pump failure.