Effects of cyclosporine A on the functions of submandibular and parotid glands of rats.

1. The present study was designed to investigate the possible effects of long-term (45 days) administration of therapeutic doses of cyclosporine A (25 mg/kg/day), on the functions of submandibular and parotid glands of rats. Pure submandibular and parotid saliva were collected intraorally by microcannulation of the ducts. 2. The weight gains of the treated animals during the study and the weights of the salivary glands at the end of 45 days were reduced significantly as compared with those of controls. 3. Sialochemistry studies revealed a marked decrease in total protein concentration in saliva obtained from submandibular glands (P < 0.05). 4. Determination of electrolyte concentrations in saliva of submandibular gland and serum showed considerable differences between treated and control groups. 5. Significant elevation of amylase activity in serum and parotid saliva was observed in the treated rats in comparison with controls (P < 0.001). 6. Data presented here indicates that long-term administration of therapeutic doses of cyclosporine A causes significant alterations in salivary output and composition.