Zhonghua zhong liu za zhi [Chinese journal of oncology] · 1997
[Inherent mdr-1 gene expression in fresh tumor tissue specimens from several high-incidence malignancies].
Аннотация на английскомСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Yin L, Chen K, Li D
Аннотация
OBJECTIVE: To ascertain frequency of inherent mdr-1 gene expression in several common neoplasms.
METHODS: One hundred fifty one surgically resected tumor specimens confirmed pathologically to be malignant from preoperatively untreated cancer patients were studied. Expression of mdr-1 gene was examined by RT-PCR.
RESULTS: The frequency of primary mdr-1 gene expression was 33.3% for cancer of the stomach and gastric cardia (17/51), 37% for cancer of the esophagus (17/46), 31.3% for cancer of the colon and rectum (5/16), 13.2% for cancer of the breast (2/15), 40.0% for cancer of the thyroid (4/10), 55.0% for cancer of the lung (5/9) and 0% for cancer of the uterine cervix (0/4).
CONCLUSION: Primary mdr-1 gene expression is relatively of frequent occurrence as detected by RT-PCR technique.
METHODS: One hundred fifty one surgically resected tumor specimens confirmed pathologically to be malignant from preoperatively untreated cancer patients were studied. Expression of mdr-1 gene was examined by RT-PCR.
RESULTS: The frequency of primary mdr-1 gene expression was 33.3% for cancer of the stomach and gastric cardia (17/51), 37% for cancer of the esophagus (17/46), 31.3% for cancer of the colon and rectum (5/16), 13.2% for cancer of the breast (2/15), 40.0% for cancer of the thyroid (4/10), 55.0% for cancer of the lung (5/9) and 0% for cancer of the uterine cervix (0/4).
CONCLUSION: Primary mdr-1 gene expression is relatively of frequent occurrence as detected by RT-PCR technique.