[Study on seroprevalence of Helicobacter pylori infection among upper digestive tract cancer patients and their kindreds].

OBJECTIVE

In order to analyse the association between Hp infection and the risk of upper-digestive tract cancer.

METHODS

In Huaian and Pizhou cities, Jiangsu province, Hp IgG quantitative-enzyme-immunoassay methods was used to identify IgG to H.pylori in the serum of 312 cases of upper-digestive tract cancer patients and their kindreds.

RESULTS

(1) The level of IgG to H. pylori and the IgG positive rate (50.0%) in gastric cancer patients were both higher than that of cardia and esophageal cancer patients (P > 0.05, chi 2 test) but no significant differences were observed between cardia and esophageal cancer patients, 3 types of cancer patients and their kindreds; (2) the overall positive rates of both patients and kindreds in gastric cancer families (27.1%) were significantly higher than that of cardia or esophageal cancer families (P < 0.05) but no significant differences were observed between cardia and esophageal groups.

CONCLUSION

H.pylori infection was not thought to be correlated with the development of gastric cancer, although higher clustering of Hp infection in families afflicted with gastric cancer was noticed.