Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2019
Small airway dysfunction may be an indicator of early asthma: findings from high-resolution CT.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Jiang Dan, Wang Zhimin, Shen Cong, Jin Chenwang, Yu Nan, Wang Jun, Yin Nan, Guo Youmin
Аннотация
BACKGROUND: Increasing attention is now focused on the role of the small airways in asthma. Patients with small airway asthma typically have a preserved forced expiratory volume in 1 second, with disproportionate small airway dysfunction.
OBJECTIVE: The aim of this study was to determine whether there are structural changes in the large airways in patients with small airway asthma.
METHODS: Nine patients with small airway asthma and 20 healthy controls underwent high-resolution computed tomography (HRCT) scan. The apicoposterior segmental bronchus in the left upper lobe (LB1+2) and the posterior basal segmental bronchus in the left lower lobe (LB10) were identified on HRCT images. The luminal area (LA), wall area (WA), and wall area percentage (WA%) of each bronchus were measured from the 2nd (lobar) to the 6th generation and compared between the patients with small airway asthma and the healthy controls.
RESULTS: The WA% of the 6th generation in the patients with small airway asthma was higher than that in the healthy controls; the difference was statistically significant (LB1 + 2, P = .040; LB10, P = .033).
CONCLUSION: Structural changes in the large airways of patients with small airway asthma may represent an early stage of asthma.
OBJECTIVE: The aim of this study was to determine whether there are structural changes in the large airways in patients with small airway asthma.
METHODS: Nine patients with small airway asthma and 20 healthy controls underwent high-resolution computed tomography (HRCT) scan. The apicoposterior segmental bronchus in the left upper lobe (LB1+2) and the posterior basal segmental bronchus in the left lower lobe (LB10) were identified on HRCT images. The luminal area (LA), wall area (WA), and wall area percentage (WA%) of each bronchus were measured from the 2nd (lobar) to the 6th generation and compared between the patients with small airway asthma and the healthy controls.
RESULTS: The WA% of the 6th generation in the patients with small airway asthma was higher than that in the healthy controls; the difference was statistically significant (LB1 + 2, P = .040; LB10, P = .033).
CONCLUSION: Structural changes in the large airways of patients with small airway asthma may represent an early stage of asthma.