Effects of platelet-rich plasma on sinus bone graft: meta-analysis.

BACKGROUND

This meta-analysis investigates the effects of platelet-rich plasma (PRP) on the sinus bone graft.

METHODS

PubMed, the Cochrane Library, and EMBASE were searched in January 2010.

RESULTS

Of 61 articles searched, eight controlled clinical trials, which included a total of 352 sinus bone graft cases in 191 patients, were included in the final analysis. In the fixed-effects meta-analysis, the implant survival was not significantly different between two groups in the patient-based data of four studies (relative risk [RR]: 1.02; 95% confidence interval [CI]: 0.97 to 1.08) and in the implant-based data of three studies (RR: 1.02; 95% CI: 0.99 to 1.04). The bone formation was significantly greater in the intervention group in the random-effects model (standardized mean difference [SMD]: 1.30; 95% CI: 0.21 to 2.39) in five studies with significant heterogeneity (I(2) = 76.2%). The bone-to-implant contact was not significantly different between two groups in the random-effects model (SMD: 1.02; 95% CI: -1.65 to 3.70) in two studies with significant heterogeneity (I(2) = 82.4%).

CONCLUSION

The present study indicates that there was sufficient evidence to support the use of PRP for bone formation on a sinus bone graft, whereas there was no significant effect on the implant survival and bone-to-implant contact.