Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology · 2005
[Expression of Nestin, CK19, insulin, glucagon and somatostatin in embryonic pancreas].
Аннотация на английскомСтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Yan Kai-ming, Li Ai-dong, Yang Hui-jun, Mei Yan, Zhou Hong-ying
Аннотация
AIM: To investigate the expression of Nestin, CK19, insulin, glucagon and somatostatin in the development of embryonic pancreas.
METHOD: Sample collection was conducted in accordance to the principle of informed consent. Immunohistochemical SABC method and LAB-SA for double satining were used to study the expression of the molecules in human embryonic pancreas.
RESULTS: (1) There are few nestin-positive cells in the stroma of the embryonic pancreas. CK19 is consistently expressed in the epithelial cells of pancreatic ducts. (2) From 7 weeks of gestation, pancreatic duct epithelial cells begin to differentiate into insulin, glucagon and somatostatin-positive cells.
CONCLUSION: Nestin-positive pancrease stem cells are in the stroma of human embryonic pancrease. Pancreatic duct epithelial cells differentiate into islet cells secreting insulin at the early stage of embryonic development.
METHOD: Sample collection was conducted in accordance to the principle of informed consent. Immunohistochemical SABC method and LAB-SA for double satining were used to study the expression of the molecules in human embryonic pancreas.
RESULTS: (1) There are few nestin-positive cells in the stroma of the embryonic pancreas. CK19 is consistently expressed in the epithelial cells of pancreatic ducts. (2) From 7 weeks of gestation, pancreatic duct epithelial cells begin to differentiate into insulin, glucagon and somatostatin-positive cells.
CONCLUSION: Nestin-positive pancrease stem cells are in the stroma of human embryonic pancrease. Pancreatic duct epithelial cells differentiate into islet cells secreting insulin at the early stage of embryonic development.