Fertility and sterility · 2004
Estrogen receptor alpha and beta expression in uterine leiomyomas from premenopausal women.
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Jakimiuk Artur J, Bogusiewicz Michal, Tarkowski Rafal, Dziduch Piotr, Adamiak Aneta, Wróbel Andrzej, Haczyński Józef, Magoffin Denis A, Jakowicki Jerzy A
Аннотация
OBJECTIVE: To measure messenger RNA levels of estrogen receptor (ER) alpha and beta in uterine leiomyomas, normal myometrium, and endometrium.
DESIGN: Prospective study.
SETTING: University hospital.
PATIENT(S): Seventeen premenopausal women who underwent surgery due to symptomatic uterine leiomyomas.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Quantitative RT-PCR was used for evaluation of ERalpha and ERbeta expression. Results were normalized to total cellular DNA.
RESULT(S): Expression of ERalpha and ERbeta did not differ between leiomyomas and myometrium; however, in both tissues, expression of ERalpha was significantly higher than that of ERbeta. Estrogen receptor-alpha expression in endometrium was lower than in leiomyomas and myometrium. In leiomyomas and endometrium, correlations between expression of ERalpha and ERbeta were found.
CONCLUSION(S): Uterine leiomyomas, myometrium, and endometrium display distinct patterns of ER expression.
DESIGN: Prospective study.
SETTING: University hospital.
PATIENT(S): Seventeen premenopausal women who underwent surgery due to symptomatic uterine leiomyomas.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Quantitative RT-PCR was used for evaluation of ERalpha and ERbeta expression. Results were normalized to total cellular DNA.
RESULT(S): Expression of ERalpha and ERbeta did not differ between leiomyomas and myometrium; however, in both tissues, expression of ERalpha was significantly higher than that of ERbeta. Estrogen receptor-alpha expression in endometrium was lower than in leiomyomas and myometrium. In leiomyomas and endometrium, correlations between expression of ERalpha and ERbeta were found.
CONCLUSION(S): Uterine leiomyomas, myometrium, and endometrium display distinct patterns of ER expression.