Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2004
[The effect of propofol on isolated human pregnant uterine muscles].
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Luo Dong, Wang Quan-yun, Huang Wei, Lü Sheng, Kong Gu-ya
Аннотация
OBJECTIVE: To investigate the effects of propofol on spontaneous contractions of isolated human pregnant myometrial smooth muscles.
METHODS: Twenty isolated human pregnant myometrial muscle strips with rhythmic spontaneous contraction were randomly divided into two groups: control group (n=10) and propofol group (n=10). In propofol group propofol was added cumulatively. The changes of uterine contraction were monitored.
RESULTS: Propofol at concentration of 0. 5 microg/ml and 2 microg/ml had no effect on the spontaneous contraction of isolated human pregnant uterine muscles; propofol at concentration of 5 microg/ml and 10 microg/ml could significantly reduce the spontaneous contraction of isolated human pregnant uterine muscles; the higher the concentration was, the more would be the reduction. The effect could be blocked by oxytocin (140 +/- 50) microU/ml.
CONCLUSION: Propofol could significantly reduce the spontaneous rhythmic contractions of isolated human pregnant myometrial smooth muscles in concentration-dependent manner. Oxytocin could antagonize the action.
METHODS: Twenty isolated human pregnant myometrial muscle strips with rhythmic spontaneous contraction were randomly divided into two groups: control group (n=10) and propofol group (n=10). In propofol group propofol was added cumulatively. The changes of uterine contraction were monitored.
RESULTS: Propofol at concentration of 0. 5 microg/ml and 2 microg/ml had no effect on the spontaneous contraction of isolated human pregnant uterine muscles; propofol at concentration of 5 microg/ml and 10 microg/ml could significantly reduce the spontaneous contraction of isolated human pregnant uterine muscles; the higher the concentration was, the more would be the reduction. The effect could be blocked by oxytocin (140 +/- 50) microU/ml.
CONCLUSION: Propofol could significantly reduce the spontaneous rhythmic contractions of isolated human pregnant myometrial smooth muscles in concentration-dependent manner. Oxytocin could antagonize the action.