Fertility and sterility · 2000
Hierarchical logistic regression models for clustered binary outcomes in studies of IVF-ET.
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Hogan J W, Blazar A S
Аннотация
OBJECTIVE: To describe a hierarchical logistic regression model for clustered binary data, apply it to data from a study on the effect of hydrosalpinx on embryo implantation, and compare the results with analyses that do not account for clustering.
DESIGN: Observational study.
SETTING: Academic research environment.
PATIENT(S): Women undergoing IVF-ET for tubal disease.
MAIN OUTCOME MEASURE(S): Odds of per embryo implantation.
RESULT(S): Although regression estimates are largely similar between the models, the hierarchical model properly reflects the added variation due to clustering. Standard errors are higher, confidence intervals are wider, and P values indicate fewer "statistically significant" effects.
CONCLUSION(S): Ignoring important sources of variation in any analysis can lead to incorrect confidence intervals and P values. In studies of IVF-ET, where clustered data are common, unexplained heterogeneity can be substantial. In this setting, hierarchical logistic regression is an appropriate alternative to standard logistic regression.
DESIGN: Observational study.
SETTING: Academic research environment.
PATIENT(S): Women undergoing IVF-ET for tubal disease.
MAIN OUTCOME MEASURE(S): Odds of per embryo implantation.
RESULT(S): Although regression estimates are largely similar between the models, the hierarchical model properly reflects the added variation due to clustering. Standard errors are higher, confidence intervals are wider, and P values indicate fewer "statistically significant" effects.
CONCLUSION(S): Ignoring important sources of variation in any analysis can lead to incorrect confidence intervals and P values. In studies of IVF-ET, where clustered data are common, unexplained heterogeneity can be substantial. In this setting, hierarchical logistic regression is an appropriate alternative to standard logistic regression.