Stromomyomas of the uterus-- importance of total circumferential evaluation of the margin.

Four stromomyomas were extensively dissected to represent the entire circumference of the uterus on sequential histologic sections. In all cases the smooth muscle component was extensive, and irregular interdigitation of stromal neoplasia with a smooth muscle component made evaluation of the margin difficult. It was impossible to determine where the smooth muscle component of the neoplasm ended and where peritumoral normal myometrium began. This makes the detection of vascular invasion more important. At the end of a thorough evaluation of sections, large vessel invasion was found on the circumference of three stromomyomas in a particular foci of the margin. Extensive circumferential evaluation of the margin has been evaluated as a promising procedure to allow effective distinction of stromomyomas with focal angioinvasion.