Nephrotoxicity following single dose mithramycin therapy.

Mithramycin given as a single dose for the treatment of hypercalcemia has not been reported to cause renal dysfunction. A case is presented of nephrotoxicity following a single 25 micrograms/kg dose in a patient with underlying squamous cell carcinoma, obstructive uropathy, and hypercalcemia. Underlying renal impairment may magnify the nephrotoxicity of mithramycin.