Fertility and sterility · 2011
A pituitary adenoma secreting follicle-stimulating hormone with ovarian hyperstimulation: treatment using a gonadotropin-releasing hormone antagonist.
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Garmes Heraldo Mendes, Grassiotto Oswaldo Rocha, Fernandes Yvens Barbosa, Queiroz Luciano de Souza, Vassalo José, de Oliveira Daniel Minutti, Benetti-Pinto Cristina Laguna
Аннотация
OBJECTIVE: To describe the management of a patient with a pituitary adenoma secreting follicle-stimulating hormone (FSH) associated with ovarian hyperstimulation who was treated with a gonadotropin-releasing hormone (GnRH) antagonist.
DESIGN: Case report.
SETTING: University teaching hospital.
PATIENT(S): A woman of reproductive age with secondary amenorrhea and ovarian hyperstimulation due to a pituitary adenoma secreting FSH, which persisted after transsphenoidal surgery.
INTERVENTION(S): Clinical treatment with a GnRH antagonist.
MAIN OUTCOME MEASURE(S): A decrease in serum estradiol levels.
RESULT(S): During the treatment period, ovarian hyperstimulation decreased as shown by a reduction in estradiol levels and an improvement in the patient's clinical condition and in the ultrasonography parameters.
CONCLUSION(S): The GnRH antagonist was found to be effective for the short-term treatment of ovarian hyperstimulation secondary to a pituitary adenoma secreting FSH, thus representing a therapeutic option that should be taken into consideration in such cases.
DESIGN: Case report.
SETTING: University teaching hospital.
PATIENT(S): A woman of reproductive age with secondary amenorrhea and ovarian hyperstimulation due to a pituitary adenoma secreting FSH, which persisted after transsphenoidal surgery.
INTERVENTION(S): Clinical treatment with a GnRH antagonist.
MAIN OUTCOME MEASURE(S): A decrease in serum estradiol levels.
RESULT(S): During the treatment period, ovarian hyperstimulation decreased as shown by a reduction in estradiol levels and an improvement in the patient's clinical condition and in the ultrasonography parameters.
CONCLUSION(S): The GnRH antagonist was found to be effective for the short-term treatment of ovarian hyperstimulation secondary to a pituitary adenoma secreting FSH, thus representing a therapeutic option that should be taken into consideration in such cases.