Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns · 1999
[The origin of calcitonin gene-related peptide (CGRP) in burned skin of rats].
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Wang B, Chen B, Hu D
Аннотация
OBJECTIVE: To investigate the origin of calcitonin gene related-peptide (CGRP) in skin burn wound.
METHODS: Immunohistochemistry technique was used to determine change in distributive density in CGRP-containing nerve fibers in the wound, wound margin, remote intact skin of rats during the first 96 hours postburn.
RESULTS: It was shown that the distributive density of CGRP-containing nerve fibers in all areas decreased at 15 min postburn, but the density recovered earlier in wound margins compared to other sites. In addition, CGRP immunoreactive positive cells, which emigrated from blood vessel in dermis underneath the wound and wound margin, were related to CGRP-containing nerve fibers at 12 hours. Stronger staining intensity to CGRP was observed in those cells and they disintegrated and released CGRP immunoreactive materials into the dermis at 24 hours. Thereafter, those cells disappeared.
CONCLUSION: CGRP not only is released from cutaneous nerve, but also is synthesized and released by immune cells in response to burns.
METHODS: Immunohistochemistry technique was used to determine change in distributive density in CGRP-containing nerve fibers in the wound, wound margin, remote intact skin of rats during the first 96 hours postburn.
RESULTS: It was shown that the distributive density of CGRP-containing nerve fibers in all areas decreased at 15 min postburn, but the density recovered earlier in wound margins compared to other sites. In addition, CGRP immunoreactive positive cells, which emigrated from blood vessel in dermis underneath the wound and wound margin, were related to CGRP-containing nerve fibers at 12 hours. Stronger staining intensity to CGRP was observed in those cells and they disintegrated and released CGRP immunoreactive materials into the dermis at 24 hours. Thereafter, those cells disappeared.
CONCLUSION: CGRP not only is released from cutaneous nerve, but also is synthesized and released by immune cells in response to burns.