The Healing Effect of Platelet-rich Plasma (PRP) Jelly in Rabbits Undergoing Tracheal Resection and Anastomosis.

BACKGROUND/AIM: Tracheal anastomosis is commonly indicated for patients with tracheal tumor, stenosis and tracheoesophageal fistula. This study was designed to evaluate the healing activity of topical application of platelet-rich plasma (PRP) jelly for tracheal reconstruction in a rabbit model.

MATERIALS AND

METHODS

Thirty-six healthy New Zealand White rabbits were assigned to three groups of 12 animals each. The control group underwent tracheal resection and anastomosis. The fibrin-glue group and PRP-jelly group underwent tracheal resection and anastomosis plus fibrin glue or PRP jelly application over the anastomosis and surgical field, respectively.

RESULTS

The PRP jelly treatment enhanced the healing capacity by positive effects on healing rate, tissue fill, and volume fraction of fibroblasts during the 28 days following surgery.

CONCLUSION

Application of PRP jelly to tracheal anastomotic wounds can accelerate or improve the quality of repair.