Preoperative Glucose-Albumin Ratio and Its Association with Postoperative Outcomes in Critically Ill Adult Burn Patients: A Retrospective Cohort Study of 1119 Patients.

Background/Objectives: Severe burn injury is associated with high postoperative morbidity and mortality due to profound metabolic and nutritional stress. The blood glucose-to-serum albumin ratio (GAR) may reflect both metabolic derangement and nutritional status, but its prognostic significance in burn intensive care unit (ICU) patients remains unclear. This study evaluated the association between preoperative GAR and postoperative outcomes in adult burn ICU patients undergoing surgery. Methods: We retrospectively analyzed adult burn ICU patients who underwent surgery between 2014 and 2024. GAR was calculated using blood glucose and serum albumin levels measured within one day before surgery. The primary outcome was 90-day postoperative mortality. Secondary outcomes included 90-day hospital-free days and ICU-free days. Multivariable Cox regression and restricted cubic spline analyses were performed to assess the relationship between GAR and mortality risk. Receiver operating characteristic curve analysis was used to evaluate the discriminatory performance of GAR and determine the optimal cutoff value. Results: Among 1119 patients, the 90-day mortality rate was 25.6%. Higher preoperative GAR was independently associated with increased 90-day mortality in multivariable Cox regression analysis. Restricted cubic spline analysis demonstrated a significant overall association, with progressively increasing mortality risk at higher GAR levels. Receiver operating characteristic curve analysis showed moderate discriminatory performance (area under the curve = 0.789), and the optimal cutoff value based on the highest Youden index was 62.5. Patients with GAR ≥ 62.5 had significantly lower 90-day survival rates and fewer 90-day hospital-free days and ICU-free days than those with lower GAR values (all p < 0.001). Conclusions: Higher preoperative GAR was significantly associated with adverse postoperative outcomes, including increased 90-day mortality and fewer hospital-free and ICU-free days in adult burn ICU patients.