Optimizing the multidisciplinary management of vulvar and vaginal cancers: A position paper from Italian experts.

Vulvar and vaginal cancers represent rare malignancies for which high-quality evidence remains scarce, largely due to their low incidence and biological heterogeneity. Therefore, the clinical management of these tumors poses significant challenges for multidisciplinary teams. To address this unmet need, an interdisciplinary expert panel developed the present position paper based on the best available evidence regarding surgical, locoregional and systemic treatment strategies. In addition, considerations relevant to the care of transgender and gender-diverse individuals are incorporated. This document aims to support multidisciplinary clinical decision-making in vulvar and vaginal cancers by synthesising current evidence, identifying areas of uncertainty, and outlining available resources to promote the implementation of structured, evidence-informed, and patient-centered treatment approaches.