Anticancer research · 2003
Radiotherapy alone and chemoirradiation in recurrent squamous cell carcinoma of the vulva.
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Raffetto Nicola, Tombolini Vincenzo, Santarelli Mario, Valeriani Maurizio, Galla Domenico A, Enrici Riccardo Maurizi
Аннотация
AIM: To evaluate the role of radiotherapy alone or combined with chemotherapy in the treatment of recurrent vulvar cancer, emphasising the prognostic factors and outcomes.
MATERIALS AND METHODS: Twenty women with loco-regional recurrence of vulvar carcinoma were retrospectively reviewed. Eleven patients were managed with a combination of chemotherapy and radiotherapy, seven out of these with concomitant radio-chemotherapy and four with neo-adjuvant chemotherapy. Nine patients were submitted to radiotherapy alone. The total dose of radiation therapy ranged from 30 Gy to 70 Gy.
RESULTS: The median follow-up was 6 months (range 2-70 months). The 5-year overall and disease-free survival for the entire cohort was 20%. The outcomes included 6 complete response (CR), 10 partial response (PR) and 4 no change (NC). Patients with one site of recurrence and size of lesion < or = 3 cm were long survivors and disease-free at 5 years; all these women received a total dose of radiation therapy > or = 6480 cGy.
CONCLUSION: We emphasize the importance of the number, site and diameter of recurrences as prognostic indicators; the outcomes of these patients were also affected by the total dose of radiation therapy.
MATERIALS AND METHODS: Twenty women with loco-regional recurrence of vulvar carcinoma were retrospectively reviewed. Eleven patients were managed with a combination of chemotherapy and radiotherapy, seven out of these with concomitant radio-chemotherapy and four with neo-adjuvant chemotherapy. Nine patients were submitted to radiotherapy alone. The total dose of radiation therapy ranged from 30 Gy to 70 Gy.
RESULTS: The median follow-up was 6 months (range 2-70 months). The 5-year overall and disease-free survival for the entire cohort was 20%. The outcomes included 6 complete response (CR), 10 partial response (PR) and 4 no change (NC). Patients with one site of recurrence and size of lesion < or = 3 cm were long survivors and disease-free at 5 years; all these women received a total dose of radiation therapy > or = 6480 cGy.
CONCLUSION: We emphasize the importance of the number, site and diameter of recurrences as prognostic indicators; the outcomes of these patients were also affected by the total dose of radiation therapy.