Zhonghua fu chan ke za zhi · 2002
[Clinicopathologic analysis of aggressive angiomyxoma in the pelvis and vulva of 8 cases].
Аннотация на английскомСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Liao Qinping, Liu Zhaohui, Zhang Yan, He Qun
Аннотация
OBJECTIVE: To study the clinical and pathologic features of aggressive angiomyxoma (AAM) and its occurrence, treatment and prognosis.
METHODS: The 8 cases of AAM were analyzed retrospectively, among which 6 cases in vulva, 2 cases in perineum, vagina and pelvis. As well we performed immunohistochemical studies.
RESULTS: The neoplastic cells were at least focally immunoreactive for vimentin (7/7), smooth muscle actin (7/7), factor 8 (7/7), proliferating cell nuclear antigen (4/7), estrogen (3/7) and progesterone (4/7) receptors. All of the examined tumors were negative for S100 protein and cluster designation 68.
CONCLUSIONS: AAM is an uncommon mesenchymal tumor that preferentially involves the pelvic and perineal regions of females. In immunohistochemical investigation the neoplastic cells of AAM exhibit fibroblastic and myofibroblastic features. They are characterized by slow growth, infiltration of adjacent structures, absence of distant metastases, a tendency to recur locally and a fairly good prognosis. Treatment should consist of wide surgical excision, as complete as technically possible.
METHODS: The 8 cases of AAM were analyzed retrospectively, among which 6 cases in vulva, 2 cases in perineum, vagina and pelvis. As well we performed immunohistochemical studies.
RESULTS: The neoplastic cells were at least focally immunoreactive for vimentin (7/7), smooth muscle actin (7/7), factor 8 (7/7), proliferating cell nuclear antigen (4/7), estrogen (3/7) and progesterone (4/7) receptors. All of the examined tumors were negative for S100 protein and cluster designation 68.
CONCLUSIONS: AAM is an uncommon mesenchymal tumor that preferentially involves the pelvic and perineal regions of females. In immunohistochemical investigation the neoplastic cells of AAM exhibit fibroblastic and myofibroblastic features. They are characterized by slow growth, infiltration of adjacent structures, absence of distant metastases, a tendency to recur locally and a fairly good prognosis. Treatment should consist of wide surgical excision, as complete as technically possible.