Current eye research · 2025
Correlations of Thioredoxin and Thioredoxin Interacting Protein with Type 2 Diabetes Mellitus Complicated with Diabetic Retinopathy.
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Liu Jiasu, Yu Xuebin, Chudhary Maryam, Qi Hui, Zhang Na, Zhong Shiwen, Zhao Qi, Ren Xiang, Kong Hui, Kong Li
Аннотация
PURPOSE: To investigate the relationship between Thioredoxin (Trx), Thioredoxin interacting protein (Txnip), and the severity of diabetic retinopathy (DR).
METHODS: The study involved a total of 101 eyes, comprising of 31 healthy controls, 24 diabetic patients with no clinically detectable retinopathy (NDR group), 26 patients with non-proliferative DR (NPDR group), and 20 patients with proliferative DR (PDR group), including 62 males and 49 females, average aged 61.65 ± 9.4. Retinal morphology was evaluated using spectral domain optical coherence tomography (SD-OCT), while retinal function was assessed using full-field electroretinogram (ffERG) to record the amplitudes and implicit time. The correlation between serum Trx, Txnip, and DR was analyzed using Spearman correlation analysis.
RESULTS: In the early stage of DR, there was no significant difference in macular retinal thickness between groups; in the PDR group, there was a significant increase compared to both the NDR and control groups, particularly in the central fovea (p < 0.0001). Additionally, the amplitude and implicit time of oscillatory potentials exhibited a significant difference between the NDR and control groups at an early stage of DR (p < 0.001). Furthermore, the amplitude of rod and cone ERG decreased significantly in the early stage of DR, while the implicit time began to decline in the NPDR stage. The serum levels of Trx and Txnip exhibited a positive correlation with the progression of DR (r = 0.851, 0.762). Conversely, a negative correlation was observed between the serum levels of Trx and Txnip and the amplitudes of ERG, while a positive correlation was observed with the implicit time of ERG.
CONCLUSIONS: The serum levels of Trx and Txnip exhibit a positive correlation with retinopathy associated with type 2 diabetes mellitus (T2DM), and thus may be utilized as a potential target for the timely diagnosis and treatment of DR.
METHODS: The study involved a total of 101 eyes, comprising of 31 healthy controls, 24 diabetic patients with no clinically detectable retinopathy (NDR group), 26 patients with non-proliferative DR (NPDR group), and 20 patients with proliferative DR (PDR group), including 62 males and 49 females, average aged 61.65 ± 9.4. Retinal morphology was evaluated using spectral domain optical coherence tomography (SD-OCT), while retinal function was assessed using full-field electroretinogram (ffERG) to record the amplitudes and implicit time. The correlation between serum Trx, Txnip, and DR was analyzed using Spearman correlation analysis.
RESULTS: In the early stage of DR, there was no significant difference in macular retinal thickness between groups; in the PDR group, there was a significant increase compared to both the NDR and control groups, particularly in the central fovea (p < 0.0001). Additionally, the amplitude and implicit time of oscillatory potentials exhibited a significant difference between the NDR and control groups at an early stage of DR (p < 0.001). Furthermore, the amplitude of rod and cone ERG decreased significantly in the early stage of DR, while the implicit time began to decline in the NPDR stage. The serum levels of Trx and Txnip exhibited a positive correlation with the progression of DR (r = 0.851, 0.762). Conversely, a negative correlation was observed between the serum levels of Trx and Txnip and the amplitudes of ERG, while a positive correlation was observed with the implicit time of ERG.
CONCLUSIONS: The serum levels of Trx and Txnip exhibit a positive correlation with retinopathy associated with type 2 diabetes mellitus (T2DM), and thus may be utilized as a potential target for the timely diagnosis and treatment of DR.