Journal of hepato-biliary-pancreatic sciences · 2025
Clinical Impact for Prognostic Index of Nodal Stations and Reconsideration of Optimal Regional Lymph Node Station in Pancreatic Cancer.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Yamada Suguru, Fujii Tsutomu, Oshima Kenji, Nomoto Kosuke, Oshima Yukiko, Hayashi Masamichi, Nakao Akimasa
Аннотация
PURPOSES: Regional lymphadenectomy is standard in pancreatic cancer. The aim was to explore clinical impact for the prognostic index of nodal stations and optimal extent of lymphadenectomy in pancreatic cancer.
METHODS: A total of 507 consecutive pancreatic cancer patients who underwent a surgery-first approach and unified systemic lymphadenectomy were enrolled. The prognostic index of nodal stations was calculated by tumor location and relevant lymph node (LN) station, and clinicopathological factors and survival outcomes were analyzed.
RESULTS: In the pancreatic head, LN13 dissection showed the highest prognostic index, with extremely low indices for LN6 and LN12 dissection. In the pancreatic body, LN11 dissection showed the highest index; LN9 and LN10 dissection both had indices of zero. In the pancreatic tail, LN11 dissection showed the highest index, and that for LN8 dissection was zero. Subgroup analyses of the prognostic index according to resectability status, peritoneal cytology, pathological stage, and the administration of postoperative adjuvant therapy were performed, and the overall pattern remained unchanged.
CONCLUSION: Regional lymphadenectomy is basically indispensable, considering LN metastasis, and the prognostic index of nodal stations showed the clinical impact on survival analysis. Also, it might be possible to omit some LN dissection based on the tumor location.
METHODS: A total of 507 consecutive pancreatic cancer patients who underwent a surgery-first approach and unified systemic lymphadenectomy were enrolled. The prognostic index of nodal stations was calculated by tumor location and relevant lymph node (LN) station, and clinicopathological factors and survival outcomes were analyzed.
RESULTS: In the pancreatic head, LN13 dissection showed the highest prognostic index, with extremely low indices for LN6 and LN12 dissection. In the pancreatic body, LN11 dissection showed the highest index; LN9 and LN10 dissection both had indices of zero. In the pancreatic tail, LN11 dissection showed the highest index, and that for LN8 dissection was zero. Subgroup analyses of the prognostic index according to resectability status, peritoneal cytology, pathological stage, and the administration of postoperative adjuvant therapy were performed, and the overall pattern remained unchanged.
CONCLUSION: Regional lymphadenectomy is basically indispensable, considering LN metastasis, and the prognostic index of nodal stations showed the clinical impact on survival analysis. Also, it might be possible to omit some LN dissection based on the tumor location.