Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2025
Comparative study of mean lung dose with different types of surgery in breast cancer patients during radiotherapy.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Al-Haidary Yahya Ali Desher, Glayl Ahmed Ghanim, Al-Maliky Sajjad Abbas Khairullah, Al Regebat Zainab Hasan, Abdul-Zahr Dalel Saad
Аннотация
UNLABELLED: Breast cancer (BC) is a highly prevalent and significant health concern influencing women worldwide. This is crucial for understanding the impact of breast cancer and developing targeted prevention and treatment strategies. The research aims to investigate the performance of the 3DCRT model by comparing BCS and MRM plans in terms of mean lung dose.
PURPOSE: A comparative analysis of MRM and BCS treatment plans was conducted to determine the most appropriate strategy for breast cancer, with an emphasis on minimizing radiation dose to the lungs.
METHODS AND MATERIALS: Breast cancer (BC) RT was performed for 174 patients' treatment planning. The treatment plans for BCS are compared to the MRM plans based on mean dose lung and target coverage. To create a 3DCRT plan for Breast cancer, applying 3DCRT in Monaco and evaluating an outcome of Breast cancer irradiation procedure, analyse the main dosimetric parameters of the planned treatment plans for BCS and MRM plans. This study divided the patients into two groups according to the type of surgery breast-conserving surgery (BCS) and modified radical mastectomy (MRM) groups. Each group is also divided into different subgroups according to the dose of radiotherapy given (4050, 4256, and 5000 cGy) and whether the lymph nodes in the axillae and the supraclavicular regions are irradiated or not have been taken into account. Different strategy plans were performed to get the best result according to the size of the PTV. The dose Prescribed for MRM was 4050 cGy, 270 cGy per fraction (270 cGy/Fx), 4256/16 fraction while BCS was 5000 cGy, 200 cGy per fraction (200 cGy/Fx), 4050/15 fraction 270 cGy per fraction (270 cGy/Fx).
RESULTS: The total number of patients in this study was 174 breast cancer patients with ages ranging from 18 to 77 years with a mean age ± SD (49.2 ± 11.5) years, and the results showed the highest incidence of breast cancer among patients in 6th (50-59 years) and they are (29.3 %) and the 5th and 7th decades of life and (23.5 %) each, while the lowest incidence of breast cancer among patients in 3rd decade of life (below 1 %).
PURPOSE: A comparative analysis of MRM and BCS treatment plans was conducted to determine the most appropriate strategy for breast cancer, with an emphasis on minimizing radiation dose to the lungs.
METHODS AND MATERIALS: Breast cancer (BC) RT was performed for 174 patients' treatment planning. The treatment plans for BCS are compared to the MRM plans based on mean dose lung and target coverage. To create a 3DCRT plan for Breast cancer, applying 3DCRT in Monaco and evaluating an outcome of Breast cancer irradiation procedure, analyse the main dosimetric parameters of the planned treatment plans for BCS and MRM plans. This study divided the patients into two groups according to the type of surgery breast-conserving surgery (BCS) and modified radical mastectomy (MRM) groups. Each group is also divided into different subgroups according to the dose of radiotherapy given (4050, 4256, and 5000 cGy) and whether the lymph nodes in the axillae and the supraclavicular regions are irradiated or not have been taken into account. Different strategy plans were performed to get the best result according to the size of the PTV. The dose Prescribed for MRM was 4050 cGy, 270 cGy per fraction (270 cGy/Fx), 4256/16 fraction while BCS was 5000 cGy, 200 cGy per fraction (200 cGy/Fx), 4050/15 fraction 270 cGy per fraction (270 cGy/Fx).
RESULTS: The total number of patients in this study was 174 breast cancer patients with ages ranging from 18 to 77 years with a mean age ± SD (49.2 ± 11.5) years, and the results showed the highest incidence of breast cancer among patients in 6th (50-59 years) and they are (29.3 %) and the 5th and 7th decades of life and (23.5 %) each, while the lowest incidence of breast cancer among patients in 3rd decade of life (below 1 %).