Archives of oral biology · 1994
The fate of glycogen in granular tubule cells of rat submandibular glands during secretory events.
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Garrett J R, Thomopoulos G N, Zhang X S, Hartley R
Аннотация
Glycogen, studied electron microscopically in granular tubule cells by means of the periodic acid-thiocarbohydrazide-silver proteinase technique, was found to be scattered abundantly throughout the cytoplasm. Parasympathetic nerve stimulation caused no detectable change in the glycogen. Degranulation of the granular tubule cells after either sympathetic nerve stimulation or cyclocytidine injection caused loss of the glycogen from the cells. Study of tubule cells undergoing secretion in the early stages after cyclocytidine injection indicated that glycogenolysis was occurring. Glycogen had reaccumulated in the cells within 24 h, before extensive reformation of the secretory granules had occurred, and remained abundant throughout the subsequent granule formation. It is concluded that glycogen provides an important source of energy during secretory degranulation of the granular tubule cells.